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2007-04-23
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Asbestos Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Although asbestos is no longer used in many products, it will remain a public health concern well into the 21st century.
- Intact asbestos sources in the home release few fibers and should be left undisturbed. Damaged or crumbling materials should be repaired or removed only by certified asbestos-removal professionals.
- Asbestos exposure is associated with parenchymal asbestosis, asbestos-related pleural abnormalities, mesothelioma, and lung cancer, and it may be associated with cancer at some extra thoracic sites.
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2008-05-23
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Beryllium Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Beryllium produces health effects ranging from sensitization without evidence of disease to clinically apparent pulmonary disease.
- Chronic beryllium disease may be misdiagnosed as sarcoidosis.
- Immunologic tests can detect beryllium sensitization and help clinicians differentiate between chronic beryllium disease and other interstitial lung diseases.
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2008-05-12
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Cadmium Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Prevention is the key to managing cadmium exposure. No effective treatment for cadmium toxicity exists.
- For the general public, the primary source of exposure to cadmium is dietary.
- Smoking tobacco adds an additional burden of cadmium.
- Nutritional deficiencies can increase the risk of cadmium toxicity.
- Chronic cadmium exposure primarily affects the kidneys and secondarily the bones.
- Acute inhalation of fumes containing cadmium affects the lungs.
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2008-12-18
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Chromium Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- The toxicity of chromium compounds depends on the oxidation state of the metal.
- Occupational exposure to chromium(VI) compounds has been associated with increased incidence of lung cancer.
- Chromium(III) is an essential nutrient that can be toxic in large doses.
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2007-10-16
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Cholinesterase Inhibitors, Including Insecticides and Chemical Warfare Nerve Agents | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Cholinesterase inhibitors are a class of compounds that includes chemical warfare nerve agents and certain insecticides.
- Fatalities occur mainly due to effects on respiration due depression of respiratory drive, paralysis of muscles of respiration, bronchoconstriction, and airway obstruction from profuse respiratory tract secretions.
- Treatment includes the use of atropine, 2-PAM, diazepam, and aggressive supportive care.
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2007-10-17
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Environmental Triggers of Asthma | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Asthma is a chronic inflammatory disease of the airways.
- Over the past decade, the prevalence of asthma in children and adults has increased in the United States.
- Environmental exposures to allergens, air pollutants, and environmental tobacco smoke, and workplace exposures can cause and exacerbate asthma.
- Control of environmental exposures can significantly improve the quality of life of people with asthma.
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2007-10-07
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Ethylene Glycol and Polyethylene Glycol Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Ethylene glycol ingestion first affects the central nervous system (CNS). After a characteristic latent period, signs of inebriation may be followed by serious illness and even death, caused by toxic metabolites.
- Propylene glycol, which is much less toxic than ethylene glycol, is metabolized to compounds that are normal constituents of the citric acid cycle.
- No health effects have been reported in persons chronically exposed to ethylene glycol or propylene glycol at levels found in the environment.
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2007-08-20
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Lead Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Children of all races and ethnic origins are at risk of lead toxicity throughout the U.S.
- Lead may cause irreversible neurological damage as well as renal disease, cardiovascular effects, and reproductive toxicity.
- Blood lead levels once considered safe are now considered hazardous, with no known threshold.
- Lead poisoning is a wholly preventable disease.
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2007-09-24
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Nitrate/Nitrite Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Nitrate toxicity is a preventable cause of methemoglobinemia.
- Infants younger than 4 months of age are at particular risk of nitrate toxicity from contaminated well water.
- The widespread use of nitrate fertilizers increases the risk of well-water contamination in rural areas..
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2008-05-12
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Taking an Exposure History | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Because many environmental diseases either manifest as common medical problems or have nonspecific symptoms, an exposure history is vital for correct diagnosis.
- By taking a thorough exposure history, the primary care clinician can play an important role in detecting, treating, and preventing disease due to toxic exposure.
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2008-05-23
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Tetrachloroethylene (PCE) Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Tetrachloroethylene is used mainly as a solvent for dry cleaning and metal degreasing.
- Like most chlorinated solvents, tetrachloroethylene can cause central nervous system depression.
- Chronic exposure to tetrachloroethylene may adversely affect the neurological system, liver, and kidneys.
- Tetrachloroethylene is reasonably anticipated to be a human carcinogen on the basis of limited evidence from studies in humans and sufficient evidence of carcinogenicity from studies in experimental animals.
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2007-11-08
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Trichloroethylne (TCE) Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Trichloroethylene (TCE) is a common industrial solvent and contaminant of hazardous waste sites, groundwater, and drinking water.
- TCE is a CNS depressant and a suspected hepatotoxin in humans.
- TCE is reasonably anticipated to be a human carcinogen based on limited evidence of carcinogenicity from studies in humans and sufficient evidence
of carcinogenicity from studies in experimental animals.
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2009-05-01
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Uranium (U) Toxicity | ATSDR - Environmental Medicine & Environmental Health Education - CSEM
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- Everyone is exposed to uranium in food, air, and water as part of the natural environment.
- Most exposures do not warrant monitoring or treatment.
- Populations most heavily exposed to uranium are those employed in mining and milling operations, or in uranium enrichment and processing activities.
- Natural and depleted uranium are primarily chemical toxicants, with radiation playing a minor role or no role at all.
- Outcomes that may occur with uranium overexposure, based on both observed human effects and animal studies, include non-malignant respiratory disease (fibrosis, emphysema) and nephrotoxicity.
- Nephrotoxicity should reverse as overexposure ceases.
- Alpha radiation (such as that from uranium) is classified as a human carcinogen. However, human studies have not found elevated rates of cancer from uranium exposure, and high-dose animal studies have not found cancer following inhalation, oral, or dermal exposure to uranium.
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